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Intelligent Surgical Robot

The intelligent surgical robot (FlexShuttle Mini) is independently developed by NeuroXess. It is designed for intelligent, pre-cise, and efficient surgeries on mice and rats in neuroscience research. It features a high degree of automation, eliminating the need for manual leveling or MRI/CT scanning of animals. It supports the implantation of flexible deep electrodes, as well as most rigid electrodes and optical fibers on the market, and enables surgeries such as optogenetics and drug injection using glass electrodes.

Based on core technologies including six-axis robotic arms, binocular recognition, three-dimensional brain region recon-struction, automatic surgical planning, and deep learning, the FlexShuttle Mini can intelligently identify the skull plane and breg-ma/lambda, locate target brain regions, plan optimal implantation paths, determine and automatically create the best craniotomy sites, perform automatic implantation, and intelligently compile and store full-process experimental data. This helps scientists achieve more accurate and faster surgical experiments.

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Rats
Mice

Intracranial implantation of flexible electrodes
Intracranial implantation of silk protein electrodes
Intracranial implantation of rigid electrodes
Intracranial implantation of optical fibers
Intracranial injection of viruses and drugs

Advantages

Rich Application Scenarios Automated Skull Surface Recognition Rapid and High-Precision Positioning User-Friendly Surgery Intelligent Positioning Highly Integrated and Mobile

Rich Application Scenarios

Automatic drilling and customizable bone window shapes to adapt to various cranial surgery experiments;
Supports implantation of NeuroXess self-developed flexible electrodes, silk protein electrodes, common rigid electrodes, optical fibers and drug injection.

Automated Skull Surface Recognition

High-resolution binocular cameras realize precise skull reconstruction;
The tilt angle of the skull surface can be automatically calculated to eliminate tedious manual skull leveling and simplify surgical procedures.

Rapid and High-Precision Positioning

Fast and accurate positioning according to target locations and end effector characteristics;
The six-axis robotic arm combined with intelligent algorithms can precisely reach target positions along pre-planned paths.

User-Friendly Surgery

Clear and concise surgical procedure guidance configured by the software according to surgical types, allowing users to operate smoothly without errors by following the guidance;
Surgical data can be displayed and recorded in real time during the operation, and users can input customized information into the system in real time;
All surgical data is systematically managed by the software after the operation.

Intelligent Positioning

The built-in standard 2D planar brain atlas for rats and mice, and a 3D brain model established based on the atlas;
Allows flexible setting and adjustment of target brain region coordinates;
Intelligently plans the optimal implantation path based on brain regions and electrode characteristics.

Highly Integrated and Mobile

Integrates robotic arms, binocular cameras, microscopes, light sources, surgical navigation, and other modules into one unit;
The movable trolley design enables flexible selection of surgical environments.

Surgical Procedure

Surgical management

·Users can view the status of all surgeries, create new surgeries, download surgical experiment reports, and invoke previously established but unperformed surgeries on the surgical management page;

·The surgical management page enables efficient management of all surgeries, allowing classification and filtering by surgery time and status.

New surgery

·Users can define key information such as animal type, target brain region/coordinates, electrode or other implant models, etc.;

·The software automatically plans the optimal implantation path based on the implantation information defined by the user;

·Users can visually preview the planned path in 3D/2D brain models and further confirm or adjust it.

Hardware self-test

·Ensure system accuracy by automatically performing visual system precision calibration;

·The self-test process is highly automated for convenient user operation.

Automatic identification of bregma/lambda

·Automatically identify the skull surface, and then automatically calculate the inclination angle of the skull surface;

·The built-in algorithm of the software can automatically identify and mark the bregma point and lambda point on the skull surface.

Automatic identification of bregma/lambda

Automatic craniotomy

·The six-axis robotic arm works with the cranial drill to automatically create a bone window at the target position;

·Supports users in defining the positions for installing screws or ground wires through automated sequential drilling as required;

·Users can select cranial drill bits of different diameters and bone window shapes according to their needs.

Automatic implantation

·Users can select different end-effectors according to the implant type, including optional configurations such as flexible electrode implanter, rigid electrode implanters, optical fiber implanters, and drug injectors;

·After replacing the end-effector, the robotic arm can automatically position itself above the craniotomy area to complete tasks such as electrode implantation and drug injection, with the operation of the end-effectors guided by the software throughout the entire process.

Product

All Host Standard Accessories Optional Accessories

Host

Mechanical arm + Vision system + Light source system

Cranial drill

Paired with the six-axis mechanical arm, the cranial drill can accurately move to the target position and drill into the skull, with a hole diameter range of 0.5-2.0 mm.

Flexible electrode implanter

Suitable for implanting flexible electrodes independently developed by NeuroXess, compatible with different models of flexible electrodes.

Rigid electrode implanter

Compatible with the silk protein electrodes independently developed by NeuroXess and common rigid electrodes such as silicon-based electrodes and microwire electrodes. It is capable of performing acute signal acquisition.

Optical fiber implanter

Used for brain implantation of optical fiber ferrules. Compatible with common optical fiber ferrules on the market.

Drug injector

Used for automated micro-viral injection or other drug injections into the brain. Equipped with a precision Hamilton microsyringe.